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Recombinant Human/Murine/Rat Activin A (CHO cell derived)

货号:120-14P-2

规格:2µg

价格:825

产品类型:细胞因子添加物

品牌:PeproTech

产品介绍

产品编号:

120-14P

别名:

Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein

描述:

Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellularproliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors andin postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin Acan be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activinreceptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.

氨基酸序列:

GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS

来源:

CHO cells

纯度:

Greater than 95% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105units/mg.

交叉反应:

Human

原产国:

USA

仅用于研究。不适用于诊断或治疗。

其他规格:

10µg、50µg、100µg、250µg、500µg、1mg

技术参数

实验方法和说明书下载

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