诺为生物

您的位置: 首页 > 产品分类 > 细胞生物学 >细胞培养 >细胞因子添加物 >Recombinant Human Sonic Hedgehog (Shh)

Recombinant Human Sonic Hedgehog (Shh)

货号:100-45-5

规格:5µg

价格:825

产品类型:细胞因子添加物

品牌:PeproTech

产品介绍

产品编号:

100-45

别名:

Hhg-1

描述:

Members of the Hedgehog (Hh) family are highly conserved proteins that are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh), are structurally related, and share a high degree of amino acid sequence identity (e.g. Shh and Ihh are 93% identical). The biologically active form of each Hh molecule is obtained by autocatalytic cleavage of their precursor proteins, and each corresponds to approximately one half of the N-terminal portion of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can be substituted for one another in experimental systems. Recombinant E. coli-derived Human Sonic Hedgehog is a 20.0 kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the naturally occurring, chemically modified, Cys residue.

氨基酸序列:

IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKISRNSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRALDITTS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGG

来源:

E.coli

纯度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to induce alkaline phosphatase production by C3H/10T1/2 (CCL-226) cells. The expected ED50 for this effect is 0.8-1.0 μg/ml.

交叉反应:

Mouse, Human

原产国:

USA

仅用于研究。不适用于诊断或治疗。

其他规格:25µg、100µg、250µg、500µg、1mg


技术参数

实验方法和说明书下载

  • 品牌
  • 产品名称
  • 货号
  • 价格
  • 操作
在线客服
热线电话
010-57438396
010-56230491

微信公众账号

登录

询价信息填写